反应详情

A mixture of 4-chloro-7-(trifluoromethyl)quinoline (1.0 g, 4.7 mmol) and of 2-aminoethanol (0.86 g, 14.1 mmol) is heated, with magnetic stirring, at 150° C. for 15 min and then 185° C. for 30 min. After returning to ambient temperature, the solid is suspended in 5 ml of a 10%, w/v, aqueous sodium hydroxide solution. The precipitate obtained is filtered off through sintered glass, washed with water and then brought to reflux in 10 ml of ethanol for 15 min. After returning to ambient temperature, water is added until a precipitate appears. The precipitate is filtered off through sintered glass, washed with 10 ml of water and then dried under vacuum. The product 10 is obtained in the form of a white powder: 0.82 g (yield=68%). Mp: 181-182° C.

1. customAfter returning to ambient temperature
2. customThe precipitate obtained
3. filtrationis filtered off through sintered glass
4. washwashed with water
5. temperatureto reflux in 10 ml of ethanol for 15 min
6. customAfter returning to ambient temperature
7. additionwater is added until a precipitate
8. filtrationThe precipitate is filtered off through sintered glass
9. washwashed with 10 ml of water
10. customdried under vacuum