1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene → HCID 18971672, compound

HRID 55089Notes

Reaction equation

HRID 55089 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[S:28])=[CH:22][C:21]=1[C:29]([F:32])([F:31])[F:30]>>[N:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:15]=[CH:16][C:7]=1[O:6][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([Cl:19])=[C:21]([C:29]([F:32])([F:30])[F:31])[CH:22]=2)=[S:28])=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 5200261-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzeneHCID 131089464-(Quinolin-2-yloxy)aniline

Product 1

HCID 18971672HCID 18971672, compound

Procedure

2-(4-Aminophenoxy)quinoline (2.4 moles, 0.56 g) and 4-chloro-3-trifluoromethylphenylisothiocyanate (2.4 moles, 0.57 g) were reacted according to procedure C to yield the title compound, 0.8 g. 70%. Mass Spec (FD) 473. Calculated for C23H15ClF3N3OS: C, 58.29; H, 3.19; N, 8.87. Found: C, 58.47; H, 3.48; N, 8.85.

Sources & evidence

ORD record
ord-5ad3930d60e54e9ea3515c2451fd15be
Source dataset
uspto-grants-1997_04
Patent number
US05624937

Reaction notes

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