2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → HCID 57445292, compound

Participants

Reaction Steps

To a solution of 130 mg of 3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide in 5 mL of tetrahydrofuran are added dropwise 85 μL of 2-fluoro-5-(trifluoromethyl)phenyl isocyanate. The reaction mixture is then stirred for 16 hours at room temperature under an argon atmosphere and then concentrated under reduced pressure. The residue obtained is chromatographed on a column of silica (eluent: 9/1 dichloromethane/methanol by volume). The fractions containing the expected product are concentrated under reduced pressure. 237 mg of 3-{4-[3-(2-fluoro-5-trifluoromethylphenyl)ureido]phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide are obtained in the form of a white solid, the characteristics of which are as follows:

Provenance & Evidence