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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 550906Generated: October 30, 2026

4-Fluoro-3-(trifluoromethyl)phenyl isocyanate → 3-{4-[3-(4-fluoro-3-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

https://huagongshe.com/reaction/550906

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-(trifluoromethyl)phenyl isocyanateHCID 2733383—
Reactant3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamideHCID 57445354—
Product3-{4-[3-(4-fluoro-3-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamideHCID 57445298—

Reaction Steps

76.5 mg of solid brown 3-{4-[3-(4-fluoro-3-trifluoromethylphenyl)ureido]-phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide are prepared as described in Example 7 starting with 3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide and 4-fluoro-3-trifluoromethylphenyl isocyanate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07947706B2
Source datasetuspto-grants-2011_05
ORD IDord-9dc9589b540a416f8fac039135978b23
Source noteuspto-grants-2011_05