3-Fluorophenyl isocyanate → HCID 57445315, compound

HRID 550923Notes

Reaction equation

HRID 550923 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:4][CH:3]=1.[F:20][C:21]1[CH:22]=[C:23]([N:27]=[C:28]=[O:29])[CH:24]=[CH:25][CH:26]=1>>[F:20][C:21]1[CH:22]=[C:23]([NH:27][C:28](=[O:29])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[C:16]4[C:11](=[N:12][CH:13]=[CH:14][CH:15]=4)[NH:10][C:9]=3[C:17]([NH2:19])=[O:18])=[CH:6][CH:7]=2)[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 1230643-Fluorophenyl isocyanateHCID 574453543-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Product 1

HCID 57445315HCID 57445315, compound

Procedure

31.5 mg of white lyophilizate 3-{4-[3-(3-fluorophenyl)ureido]phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide are prepared as described in Example 7 starting with 3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide and 3-fluorophenyl isocyanate.

Sources & evidence

ORD record
ord-e190243f60664184a9cdeae69b68eb9f
Source dataset
uspto-grants-2011_05
Patent number
US07947706B2

Reaction notes

Loading…