Benzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)- → HCID 57445316, compound

HRID 550924Notes

Reaction equation

HRID 550924 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:4][CH:3]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=1[N:32]=[C:33]=[O:34]>>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=1[NH:32][C:33](=[O:34])[NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[N:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[C:17]([NH2:19])=[O:18])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 11983909Benzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)-HCID 574453543-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Product 1

HCID 57445316HCID 57445316, compound

Procedure

50 mg of solid beige-coloured 3-{4-[3-(2-methoxy-5-trifluoromethylphenyl)-ureido]phenyl}-1H-pyrrolo[2,3-b]pyridine-2-carboxamide are prepared as described in Example 7 starting with 3-(4-aminophenyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide and 2-methoxy-5-trifluoromethylphenyl isocyanate.

Sources & evidence

ORD record
ord-f7dbe1f25e6647519d4ef5725fc80d6d
Source dataset
uspto-grants-2011_05
Patent number
US07947706B2

Reaction notes

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