Water → 6-Methyl-4H-imidazo[1,5,4-de]quinoxaline-2,5(1H,6H)-dione

HRID 551021Notes

Reaction equation

HRID 551021 reaction equation
CC1C=CC(S([N:11]2[C:21]3[C:22]4[N:13]([CH2:14][C:15](=[O:24])[N:16]([CH3:23])[C:17]=4[CH:18]=[CH:19][CH:20]=3)[C:12]2=[O:25])(=O)=O)=CC=1.O>OS(O)(=O)=O>[CH3:23][N:16]1[C:17]2[CH:18]=[CH:19][CH:20]=[C:21]3[NH:11][C:12](=[O:25])[N:13]([C:22]=23)[CH2:14][C:15]1=[O:24]

Participants

4

Reactant 2

HCID 962WaterHCID 671729911-[(4-Methylphenyl)sulfonyl]-6-methyl-4H-imidazo[1,5,4-de]quinoxaline-2,5(1H,6H)-dione

Product 1

HCID 576637316-Methyl-4H-imidazo[1,5,4-de]quinoxaline-2,5(1H,6H)-dione

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

A solution of 1-[(4-methylphenyl)sulfonyl]-6-methyl-4H-imidazo[1,5,4-de]quinoxaline-2,5(1H,6H)-dione (600 mg, 1.68 mmol) in conc. H2SO4 (3 mL) was heated at 50° C. for 30 min, then poured into H2O at 0° C. (25 mL). The resulting precipitate was isolated by filtration, washed with H2O, and dried in vacuo to give the title compound. MS: m/z=204 (M+1).

Workup

  1. customThe resulting precipitate was isolated by filtration
  2. washwashed with H2O
  3. customdried in vacuo

Sources & evidence

ORD record
ord-f31c488a28be4e4885c7c3014677db2f
Source dataset
uspto-grants-2011_05
Patent number
US07947677B2

Reaction notes

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