Hydrochloric Acid → HCID 67171426, compound

Participants

Reaction Steps

The solution of 100 mg of ethyl(3-{(5-chloro-8-hydroxyquinolin-7-yl) [(phenoxyacetyl)amino]methyl}phenyl)acetate in THF and Sodium hydroxide (aqueous, 5 eq.) were stirred at room temperature for 48 h. The reaction mixture was acidified to pH 3 with 2N aq. HCl, then concentrated. The residue was diluted with methylene chloride, washed with water, dried over sodium sulfate and concentrated. Solids were triturated with ether and filtered to give 40 mg (43%) of (3-{(5-chloro-8-hydroxyquinolin-7-yl)[(phenoxyacetyl)amino]methyl}phenyl)acetic acid as a white solid.

Provenance & Evidence