HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 44571372, compound → N-[(5-amino-8-hydroxyquinolin-7-yl)(phenyl)methyl]-2-phenoxyacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 44571372 | HCID 44571372 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[(5-amino-8-hydroxyquinolin-7-yl)(phenyl)methyl]-2-phenoxyacetamide | HCID 67171864 | 61.8% |
Reaction Steps
N-[(8-hydroxy-5-nitroquinolin-7-yl)(phenyl)methyl]-2-phenoxyacetamide (4.0 g, 9.31 mmol), 10% Pd/C (420 mg) in 70 ml THF were hydrogenated at 42 psi for 20 h. The reaction mixture was filtered through Celite 545, dried over sodium sulfate and concentrated to afford 2.3 g of N-[(5-amino-8-hydroxyquinolin-7-yl)(phenyl)methyl]-2-phenoxyacetamide as a brown foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947712B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-39bd156d5c544ea9a06ebb669c11477d |
| Source note | uspto-grants-2011_05 |