Water → HCID 57931190, compound

Participants

Reaction Steps

To a solution of lithium aluminium hydride in diethyl ether (1 M, 1.6 mL) at −78° C. was added a solution of 1′-(propylsulfonyl)-1,4′-bipiperidine-4′-carbonitrile (0.40 g, 1.34 mmol) in diethyl ether (10 mL) over 30 min. The mixture was stirred cold for 1 h then allowed to warm to room temperature and stirred for 2 h. The resultant mixture was cooled in an ice-bath and to the mixture was added water (0.17 mL), 15% NaOH solution (0.17 mL) then water (0.17 mL). The resultant white granular solid was filtered off and the filter-cake rinsed twice with diethyl ether. The filtrate was evaporated to give {[1′-(propylsulfonyl)-1,4′-bipiperidin-4′-yl]methyl}amine as a clear oil which was used in the next step without further purification; m/z (ES+) 304 (M++H).

Provenance & Evidence