Aluminium lithium hydride → HCID 16678772, compound

HRID 551148Notes

Reaction equation

HRID 551148 reaction equation
[C:1]([C:3]1([N:15]2[CH2:20][CH2:19][N:18]([C:21](OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:8][CH2:7][N:6]([S:9]([CH2:12][CH2:13][CH3:14])(=[O:11])=[O:10])[CH2:5][CH2:4]1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:21][N:18]1[CH2:17][CH2:16][N:15]([C:3]2([CH2:1][NH2:2])[CH2:8][CH2:7][N:6]([S:9]([CH2:12][CH2:13][CH3:14])(=[O:11])=[O:10])[CH2:5][CH2:4]2)[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 57931195HCID 57931195, compound

Product 1

HCID 16678772HCID 16678772, compound

Procedure

tert-Butyl 4-[4-cyano-1-(propylsulfonyl)piperidin-4-yl]piperazine-1-carboxylate was reacted with lithium aluminium hydride as in Scheme 5 to give {[4-(4-methylpiperazin-1-yl)-1-(propylsulfonyl)piperidin-4-yl]methyl}amine as a clear oil. m/z (M++H) 319.

Sources & evidence

ORD record
ord-d8ed19f41396497da53d4f8d56e26650
Source dataset
uspto-grants-2011_05
Patent number
US07947714B2

Reaction notes

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