Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

In a round bottom flask was placed tert-butyl 4-cyano-4-isobutylpiperidine-1-carboxylate (2, 17 g, 63.8 mmol) and diethyl ether (200 mL). To the flask was added HCl in dioxane (4M, 2.327 g, 63.8 mmol) and the solution stirred overnight. A fine white solid formed in suspension and was filtered with a medium frit to give 4-cyano-4-isobutylpiperidinium chloride (3) as an HCl salt in quantitative yield after washing with diethyl ether (3×50 ml). MS 167 (M+1)

Provenance & Evidence