Ammonia → HCID 57931192, compound

Participants

Reaction Steps

In a heavy wall flask was placed 1-(ethylsulfonyl)-4-isobutylpiperidine-4-carbonitrile (4, 1.4 g, 5.42 mmol) 2N ammonia in methanol (50 ml). To this was added commercially available Raney nickel slurry in water (1.393 g, 16.26 mmol). This was then agitated under hydrogen atmosphere (45 psi) at room temp for 12 hours. The catalyst was filtered off using celite and washed with MeOH (200 ml). The organics were concentrated in vacuo to give 1-[1-(ethylsulfonyl)-4-isobutylpiperidin-4-yl]methanamine (5) as a clear oil. MS 263 (M+1)

Provenance & Evidence