Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

In a round bottom flask was placed tert-butyl 4-cyano-4-(tetrahydro-2H-pyran-4-ylmethyl)piperidine-1-carboxylate (8) (5 g, 16.21 mmol), diethyl ether (200 ml), and methanol (1 ml). To this was added commercially available HCl in dioxane (4M, 0.985 ml, 32.4 mmol.). The solution was stirred overnight. A fine white solid was formed in suspension and filtered with a medium frit to give 4-cyano-4-(tetrahydro-2H-pyran-4-ylmethyl)piperidinium chloride (9) as an HCl salt in quantitative yield after washing with diethyl ether (3×50 ml). MS 209 (M+1)

Provenance & Evidence