Ammonia → HCID 67173190, compound

Participants

Reaction Steps

In a heavy wall flask was placed 1-(ethylsulfonyl)-4-(tetrahydro-2H-pyran-4-ylmethyl)piperidine-4-carbonitrile (10) (1.25 g, 4.17 mmol) and 2N ammonia in methanol (50 ml). To this was added Raney nickel slurry in water (1.073 g, 12.52 mmol) and the reaction agitated under hydrogen atmosphere (45 psi) at room temp for 12 hours. The catalyst was filtered off using celite and washed with MeOH (200 ml) and the organics were concentrated in vacuo to give 1-[1-(ethylsulfonyl)-4-(tetrahydro-2H-pyran-4-ylmethyl)piperidin-4-yl]methanamine (11) as a clear semi-solid. MS 304 (M+1)

Provenance & Evidence