Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

In a round bottom flask was placed tert-butyl 4-cyanopiperidine-1-carboxylate (1) (15 g, 71.3 mmol) and diethyl ether (500 ml). To this was added HCl in dioxane (4M, 35.7 ml, 143 mmol) and the solution stirred overnight. A fine white solid was formed in suspension and filtered with a medium frit to give 4-cyanopiperidinium chloride (13) as an HCl salt in quantitative yield after washing with diethyl ether (3×50 ml). MS 111 (M+1)

Provenance & Evidence