Thionyl Chloride → 4-Fluoro-3-methylbenzoyl chloride

HRID 551169Notes

Reaction equation

HRID 551169 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[CH3:11].S(Cl)([Cl:14])=O>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:14])=[O:7])=[CH:4][C:3]=1[CH3:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 2428284-Fluoro-3-methylbenzoic acid

Product 1

HCID 27745894-Fluoro-3-methylbenzoyl chloride

Procedure

14.00 g (90.8 mmol) 4-fluoro-3-methyl-benzoic acid are refluxed for 1 hour together with 50 ml of thionyl chloride and then evaporated down i. vac. The residue is further reacted without any more purification.

Workup

  1. customevaporated down i
  2. customThe residue is further reacted without any more purification

Sources & evidence

ORD record
ord-537573704cad42f19cec749723aabce1
Source dataset
uspto-grants-2011_05
Patent number
US07947700B2

Reaction notes

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