反应详情

7.00 g (51.8 mmol) 4-fluoro-3-methyl-benzonitrile are heated to 110° C. together with 1-N-methyl-[1,4]diazepan for 1 week with stirring. After evaporation i. vac. the residue is separated on aluminium oxide (eluant: dichloromethane) and the corresponding fractions are again purified on silica gel (eluting gradient: dichloromethane/methanol 100:1→9:1).

1. customAfter evaporation i
2. customthe residue is separated on aluminium oxide (eluant: dichloromethane)
3. customthe corresponding fractions are again purified on silica gel (eluting gradient: dichloromethane/methanol 100:1→9:1)