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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 551207Generated: October 27, 2026

4-Methylmorpholine → HCID 178427146, compound

https://huagongshe.com/reaction/551207

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylmorpholineHCID 7972—
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant(S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamineHCID 42034613—
Reactant4-(1,1-Dioxo-3-methyl-[1,2,6]thiadiazinan-2-yl)-3-methyl-benzoic acidHCID 67048460—
SolventDimethylformamideHCID 6228—
ProductHCID 178427146HCID 178427146—

Reaction Steps

Prepared analogously to Example 1f from 4-(1,1-dioxo-3-methyl-[1,2,6]thiadiazinan-2-yl)-3-methyl-benzoic acid, (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-ethylamine, TBTU and NMM in DMF with subsequent purification by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07947700B2
Source datasetuspto-grants-2011_05
ORD IDord-1b3cc150380e4a3cb6639ec08c06bb7e
Source noteuspto-grants-2011_05