化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-Chloro-4-cyano-6-(3-thienylmethyloxy)pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Thiophene-3-methanol | HCID 123570 | — |
| 反応物 | 2,6-Dichloroisonicotinonitrile | HCID 735906 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 2-Chloro-4-cyano-6-(3-thienylmethyloxy)pyridine | HCID 19957389 | — |
反応手順
Sodium hydride (0.24 g (ca.60% in mineral oil), 0.006×1.0 mol) was suspended in 20 ml of N-methyl-2-pyrrolidinone, and 3-thiophenemethanol (0.69 g, 0.006×1.0 mol) was added thereto and the resultant solution was stirred for about 30 minutes at room temperature. The resultant mixture was cooled to 4° C. with iced water, then 4-cyano-2,6-dichloropyridine (1.04 g, 0.006 mol) was added thereto and stirred for about 1.5 hour while cooling with iced water.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05624942 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-eece5abd52194311a31191def6bbd1aa |
| 出典メモ | uspto-grants-1997_04 |