反应详情

4.00 g (25.7 mmol) 3-chloro-4-fluoro-benzonitrile are heated to 60° C. in 20 ml DMSO with 8.00 g (106.5 mmol) 2-amino-1-propanol with stirring for 2 hours. Then the reaction mixture is poured into water and extracted with ethyl acetate. The combined organic phases are washed with water and sat. sodium chloride solution, dried over sodium sulphate and evaporated down i. vac.

1. extractionextracted with ethyl acetate
2. washThe combined organic phases are washed with water and sat. sodium chloride solution
3. dry with materialdried over sodium sulphate
4. customevaporated down i