HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-Fluoro-4-(6-methoxypyridin-3-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Bromo-2-fluorobenzoic acid | HCID 302681 | — |
| Reactant | (6-Methoxypyridin-3-yl)boronic acid--hydrogen chloride (1/1) | HCID 22309456 | — |
| Product | 2-Fluoro-4-(6-methoxypyridin-3-yl)benzoic acid | HCID 61777896 | — |
Reaction Steps
The title compound is prepared as described in EXAMPLE 31, Part I, but with 4-bromo-2-fluorobenzoic acid and 6-methoxypyridin-3-ylboronic acid hydrochloride as starting materials, and 10 molar equivalents of 0.4M aqueous sodium carbonate. 1H NMR (DMSO) δ 13.30 (br s, 1H), 8.59 (d, 1H), 8.11 (dd, 1H), 7.90 (t, 1H), 7.68-7.57 (m, 2H), 6.91 (d, 1H), 3.88 (s, 3H). ESI MS (M+1)+: 248.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947684B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-5b0eb9c0c0804a41b31848cd00fc1cae |
| Source note | uspto-grants-2011_05 |