4-Bromo-2-fluorobenzoic acid → HCID 46315551, compound

HRID 551280Notes

Reaction equation

HRID 551280 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:11])[CH:3]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14](B(O)O)[CH:13]=1>>[F:11][C:4]1[CH:3]=[C:2]([C:14]2[CH:13]=[N:12][CH:17]=[CH:16][CH:15]=2)[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 27343783-Pyridinylboronic acid

Product 1

HCID 46315551HCID 46315551, compound

Procedure

The title compound is prepared as described in EXAMPLE 31, Part I, but with 4-bromo-2-fluorobenzoic acid and 3-pyridinylboronic acid as starting materials. 1H NMR (DMSO) δ 8.97 (d, 1H), 8.66-8.58 (m, 1H), 8.22-8.12 (m, 1H), 8.00-7.91 (m, 1H), 7.81-7.62 (m, 2H), 7.55-7.45 (m, 1H). ESI MS (M+1)+: 218.

Sources & evidence

ORD record
ord-dd86cc18617748eb841865df12b74d16
Source dataset
uspto-grants-2011_05
Patent number
US07947684B2

Reaction notes

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