HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 5-(6-Methoxy-3-pyridinyl)-2-thiophenecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Bromothiophene-2-carboxylic acid | HCID 349115 | — |
| Reactant | (6-Methoxypyridin-3-yl)boronic acid--hydrogen chloride (1/1) | HCID 22309456 | — |
| Product | 5-(6-Methoxy-3-pyridinyl)-2-thiophenecarboxylic acid | HCID 2052639 | — |
Reaction Steps
The title compound is prepared as described in EXAMPLE 31, Part I, but with 5-bromothiophene-2-carboxylic acid and 6-methoxypyridin-3-ylboronic acid hydrochloride as starting materials, and 10 molar equivalents of 0.4M aqueous sodium carbonate. 1H NMR (DMSO) δ 13.10 (br s, 1H), 8.55 (d, 1H), 8.03 (dd, 1H), 7.66 (d, 1H), 7.50 (d, 1H), 6.90 (d, 1H). ESI MS (M+1)+: 236.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947684B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-349b88eaaed04fd88209b2451775f29e |
| Source note | uspto-grants-2011_05 |