5-(4-Carboxyphenyl)-2-hydroxypyridine → HCID 86761324, compound

Participants

Reaction Steps

The title compound is prepared as described in EXAMPLE 31, Part K, but with 4-chloro-2-piperidin-4-yl-1H-pyrrolo[3,2-c]pyridine and 4-(6-oxo-1,6-dihydropyridin-3-yl)benzoic acid as starting materials. Purification was by flash column chromatography on silica gel. 1H NMR (d4-MeOH) δ 7.99 (dd, 1H), 7.87 (d, 1H), 7.77 (d, 1H), 7.66-7.63 (m, 2H), 7.54-7.50 (m, 2H), 7.30 (dd, 1H), 6.65 (d, 1H), 6.41 (s, 1H), 3.96-3.84 (m, 1H), 3.45-3.05 (m, 4H), 2.22-2.01 (m, 2H), 1.92-1.71 (m, 2H). ESI MS (M+1)+: 433, 435 (Cl).

Provenance & Evidence