反应详情

温度

-40 °C

To a 500 mL flask fitted with a condenser, 2,6-dimethoxyphenol (10 g, 64.86 mmol) and 80 mL of anhydrous CHCl3 was added. The solution was cooled to −40° C. and NaH (60% dispersion in mineral oil, 26 mg, 0.65 mmol) was added. Another 20 mL of anhydrous CHCl3 was added followed by rapid addition of N-bromo-succinimide (12.77 g, 71.35 mmol). The reaction mixture was stirred for 1 hour at −35° C., heated to room temperature over the next 30 minutes and heated to reflux for another 30 minutes. The solvent was evaporated under vacuum overnight. The tan solid was stirred with 100 mL ether, the mixture was filtered, and the residue was washed with ether. The solvent was evaporated under vacuum to yield a tan solid, which was then dissolved in boiling hexanes. The solution was decanted from the brown oil and filtered through a pre-heated celite pad into a heated flask. The light yellow solution was allowed to cool at room temperature for 3 hours. White wooly needles were filtered off and dried to yield 217 (3.22 g, 22%). 1H NMR (CDCl3) δ 6.72 (s, 2H), 5.44 (s, 1H), 3.88 (s, 6H); 13C NMR (CDCl3) 147.47, 133.93, 110.88, 108.38, 56.33.

1. customTo a 500 mL flask fitted with a condenser
2. temperatureheated to room temperature over the next 30 minutes
3. temperatureheated
4. temperatureto reflux for another 30 minutes
5. customThe solvent was evaporated under vacuum overnight
6. stirringThe tan solid was stirred with 100 mL ether
7. filtrationthe mixture was filtered
8. washthe residue was washed with ether
9. customThe solvent was evaporated under vacuum
10. customto yield a tan solid, which
11. dissolutionwas then dissolved
12. customThe solution was decanted from the brown oil
13. filtrationfiltered through a pre-heated celite pad into a heated flask
14. temperatureto cool at room temperature for 3 hours
15. filtrationWhite wooly needles were filtered off
16. customdried