HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-Chloro-6-(3-thienylmethyloxy)-4-trifluoromethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Thiophene-3-methanol | HCID 123570 | — |
| Reactant | 2,6-Dichloro-4-(trifluoromethyl)pyridine | HCID 520968 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-6-(3-thienylmethyloxy)-4-trifluoromethylpyridine | HCID 19957414 | — |
Reaction Steps
To a mixture prepared by adding to 3-thiophenemethanol (1.27 g, 0.0093×1.2 mol) successively tetrahydrofuran and sodium hydride (0.39 g, (ca.60% in mineral oil), 0.0093×1.05 mol), 2,6-dichloro-4-trifluoromethylpyridine (2.0 g, 0.0093 mol) was added, and the resultant solution was refluxed for about 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624942 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-6dc248110a614616b79bd00cf79a9a93 |
| Source note | uspto-grants-1997_04 |