Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)phenol → 2-(3-Thienylmethyloxy)-4-trifluoromethyl-6-(meta-trifluoromethylphenoxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-6-(3-thienylmethyloxy)-4-trifluoromethylpyridine | HCID 19957414 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(3-Thienylmethyloxy)-4-trifluoromethyl-6-(meta-trifluoromethylphenoxy)pyridine | HCID 19957392 | — |
반응 단계
To a mixture prepared by adding to meta-trifluoromethylphenol (1.1 g, 0.0034×2.0 mol) successively dimethylformamide and sodium hydride (0.20 g, (ca.60% in mineral oil), 0.0034×1.5 mol), 2-chloro-6-(3-thienylmethyloxy)-4-trifluoromethylpyridine (1.0 g, 0.0034 mol) was added, and the resultant solution was refluxed for about 2 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624942 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-2ca156775e2449f1a39bc3b3ce8bd2ea |
| 출처 메모 | uspto-grants-1997_04 |