Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)phenol → 4-Dimethylamino-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloro-4-dimethylamino-6-(3-thienylmethyloxy)pyridine | HCID 19957407 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 4-Dimethylamino-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine | HCID 19957400 | — |
반응 단계
To a solution of meta-trifluoromethylphenol (1.27 g, 0.0020×4.0 mol) in 20 ml of dry N,N-dimethylacetamide, sodium hydride (0.313 g, (ca.60% in mineral oil), 0.0020×4.0 mol) was added. After the bubbling ceased, a solution of 2-chloro-4-dimethylamino-6-(3-thienylmethyloxy)pyridine (0.526 g, 0.0020 mol) in 20 ml of dry N,N-dimethylacetamide was added dropwise, then CuI (0.186 g, 0.0020×0.5 mol) was added thereto and the resultant solution was stirred for 24 hours at the temperature of 170° to 180° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624942 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-9d8ce96f1e2f4bf88603a54003fce961 |
| 출처 메모 | uspto-grants-1997_04 |