Dimethylformamide → HCID 178487445, compound
Reaction equation
Br[C:2]1[N:3]([C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]([CH:32]3CC3)=[CH:24][CH:23]=2)[C:4]([S:7]CC(NC2C=CC(C(O)=O)=CC=2Cl)=O)=[N:5][N:6]=1.Cl.NNC(N)=N.C([N:44](C(C)C)CC)(C)C.CN(C)[CH:52]=[O:53]>>[NH2:44][C:2]1[N:3]([C:22]2[C:27]3[C:26](=[CH:31][CH:30]=[C:29]([O:53][CH3:52])[CH:28]=3)[C:25]([CH3:32])=[CH:24][CH:23]=2)[C:4]([SH:7])=[N:5][N:6]=1Participants
Conditions
- Temperature
- 50 °C
Procedure
Compound 6 (826 mg, 4.4 mmol) was dissolved in 25 mL of dichloromethane. Sodium bicarbonate (15 mL, sat. solution) and thiophosgene (0.34 mL, 4.4 mmol) were added and the mixture stirred at room temperature for 1 h. Then, the organic layer was separated, dried over sodium sulfate and concentrated to afford 1.9 g, 99% yield of 4-isothiocyanato-6-methoxy-1-methylnaphthalene (7) which was used in the next step without further purification Compound 7 (1.0 g, 4.4 mmol) was dissolved in 10 mL of dimethylformamide, aminoguanidine hydrochloride salt (723 mg, 6.5 mmol) and diisopropyl ethylamine (1.14 mL, 6.5 mmol) were added and the mixture stirred at 50° C. for 18 hours. The mixture was then concentrated and to the resulting residue was added 2M aqueous sodium hydroxide solution (10 mL). The mixture was stirred at 50° C. for 18 hours and then cooled to room temperature. The resulting mixture was then neutralized with aqueous 1N HCl and the precipitate (product) collected to give 5-amino-4-(7-methoxy-4-methylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol (8). (1.14 mg, 91% yield)
Workup
- concentrationThe mixture was then concentrated and to the resulting residue
- additionwas added 2M aqueous sodium hydroxide solution (10 mL)
- stirringThe mixture was stirred at 50° C. for 18 hours
- temperaturecooled to room temperature
- customthe precipitate (product) collected
Sources & evidence
- ORD record
- ord-00ec7669e03f4ac58bafacd678142305
- Source dataset
- uspto-grants-2011_05
- Patent number
- US07947721B2
Reaction notes
Loading…