(3R)-1-methylpiperidin-3-ol → Oxo-thiophen-2-yl-acetic acid (R)-1-methyl-piperidin-3-yl ester

Participants

Reaction Steps

To a solution of oxo-thiophen-2-yl-acetyl chloride (8.9 g, 51.2 mmol) at 5° C. in DCM (50 ml) is added a solution of (R)-1-Methyl-piperidine-3-ol (5.87 g, 51 mmol) in DCM (50 ml), dropwise with stirring over 20 minutes. The resulting mixture is stirred for 18 hours at room temperature. Washing with 1 Molar sodium bicarbonate solution, drying over magnesium sulphate, filtration and evaporation then gives the title compound as a dark oil.

Provenance & Evidence