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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 551429Generated: October 27, 2026

Ethylamine → 3-(Ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-propanol

https://huagongshe.com/reaction/551429

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthylamineHCID 6341—
Reactant1-(4-fluorophenyl)-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-indazol-4-amineHCID 24938056—
Reactant3-(Ethylamino)-1,1,1-trifluoro-2-{[(1-phenyl-1H-indazol-4-yl)amino]methyl}-2-propanolHCID 59324157—
Product3-(Ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}methyl)-2-propanolHCID 59324125—

Reaction Steps

Prepared similarly to Intermediate 15 from ethylamine (2M in tetrahydrofuran) and 1-(4-fluorophenyl)-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-indazol-4-amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07947727B2
Source datasetuspto-grants-2011_05
ORD IDord-5f3d027c54444af183cb6c08b419048a
Source noteuspto-grants-2011_05