2,6-Dimethylbenzoyl chloride → HCID 59324141, compound

HRID 551482Notes

Reaction equation

HRID 551482 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:3]=1[C:4](Cl)=[O:5].[CH2:12]([NH:14][CH2:15][C:16]([CH2:22][NH:23][C:24]1[CH:32]=[C:31]([CH3:33])[CH:30]=[C:29]2[C:25]=1[CH:26]=[N:27][N:28]2[C:34]1[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=1)([OH:21])[C:17]([F:20])([F:19])[F:18])[CH3:13]>>[CH2:12]([N:14]([CH2:15][C:16]([CH2:22][NH:23][C:24]1[CH:32]=[C:31]([CH3:33])[CH:30]=[C:29]2[C:25]=1[CH:26]=[N:27][N:28]2[C:34]1[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=1)([OH:21])[C:17]([F:19])([F:20])[F:18])[C:4](=[O:5])[C:3]1[C:2]([CH3:1])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:11])[CH3:13]

Participants

3

Reactant 2

HCID 890962,6-Dimethylbenzoyl chlorideHCID 593241453-(Ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol

Product 1

HCID 59324141HCID 59324141, compound

Procedure

Prepared similarly to Example 48 from 2,6-dimethylbenzoyl chloride and 3-(ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol.

Sources & evidence

ORD record
ord-baaec4dbfcd14b09b4b38023c5689efb
Source dataset
uspto-grants-2011_05
Patent number
US07947727B2

Reaction notes

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