2-Chloro-6-methylbenzoyl chloride → 2-Chloro-N-ethyl-6-methyl-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-6-methylbenzoyl chloride	HCID 22382040	—
Reactant	3-(Ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol	HCID 59324145	—
Product	2-Chloro-N-ethyl-6-methyl-N-[3,3,3-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-hydroxypropyl]benzamide	HCID 59324131	—

Reaction Steps

Prepared similarly to Example 56 from 2-chloro-6-methylbenzoylchloride and 3-(ethylamino)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-6-methyl-1H-indazol-4-yl]amino}methyl)-2-propanol. Purification by mass directed autopreparation (System B) resulted in separation of atropisomers of the title compound:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07947727B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-cc0203edc06a4d7fa0243dea65dd8366
Source note	uspto-grants-2011_05