Ethyl bromoacetate → HCID 67151458, compound

Participants

Reaction Conditions

Reaction Steps

6-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-1H-indazole (0.15 g, 0.331 mmol), ethyl bromoacetate (0.055 g, 0.331 mmol), cesium carbonate (119 mg, 0.364 mmol) in 6 mL DMF was stirred at RT overnight and then heated to 90° C. for 35 min. The reaction was cooled and distributed between EtOAc and H2O. The organic layer was separated and concentrated in vacuo. The crude product was purified by flash chromatography with a gradient from 0-30% ethyl acetate in hexanes to yield [6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-acetic acid ethyl ester as a white solid (120 mg, 80.1%).

Provenance & Evidence