Ethyl 2-bromopropionate → HCID 52939614, compound

Participants

Reaction Steps

3-[6-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-propionic acid was prepared from 6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-1H-indazole (0.1 g, 0.221 mmol) and ethyl bromopropionate (40 mg, 0.221 mmol), as described above for [6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indazol-1-yl]-acetic acid, to yield 81 mg (83.6%) of product. LC-MS (ES) calculated for C24H20F2N2O4, 438.43; found m/z 439 [M+H]+.

Provenance & Evidence