3-[6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid → [6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-acetic acid

HRID 551506Notes

Reaction equation

HRID 551506 reaction equation
FC1C(F)=CC(C2C=CC(OCC3C=C4C(C=CN4CCC(O)=O)=CC=3)=CC=2)=C(OC)C=1.C([O:35][C:36](=[O:65])[CH2:37][N:38]1[C:46]2[C:41](=[CH:42][CH:43]=[C:44]([CH2:47][O:48][C:49]3[CH:54]=[CH:53][C:52]([C:55]4[CH:60]=[C:59]([F:61])[C:58]([F:62])=[CH:57][C:56]=4[O:63][CH3:64])=[CH:51][CH:50]=3)[CH:45]=2)[CH:40]=[CH:39]1)C>>[F:62][C:58]1[C:59]([F:61])=[CH:60][C:55]([C:52]2[CH:53]=[CH:54][C:49]([O:48][CH2:47][C:44]3[CH:45]=[C:46]4[C:41]([CH:40]=[CH:39][N:38]4[CH2:37][C:36]([OH:65])=[O:35])=[CH:42][CH:43]=3)=[CH:50][CH:51]=2)=[C:56]([O:63][CH3:64])[CH:57]=1

Participants

3

Reactant 2

HCID 529397393-[6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acidHCID 67151932[6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-acetic acid ethyl ester

Product 1

HCID 52939740[6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-acetic acid

Procedure

[6-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-acetic acid was synthesized by a procedure similar to 3-[6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid from starting material [6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-acetic acid ethyl ester to yield the product as a white solid (23 mg, 82%). LC-MS (ES) calculated for C24H19F2NO4, 423.1; found m/z 424 [M+H]+.

Sources & evidence

ORD record
ord-856cc75ff35945a6a195f27e70f0b596
Source dataset
uspto-grants-2011_05
Patent number
US07947728B1

Reaction notes

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