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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 551509Generated: October 27, 2026

tert-Butyl 6-(hydroxymethyl)-1H-indole-1-carboxylate → tert-Butyl 4-(hydroxymethyl)-1H-indole-1-carboxylate

https://huagongshe.com/reaction/551509

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 6-(hydroxymethyl)-1H-indole-1-carboxylateHCID 23560816—
ReactantTert-butyl 4-formyl-1H-indole-1-carboxylateHCID 49758854—
Producttert-Butyl 4-(hydroxymethyl)-1H-indole-1-carboxylateHCID 12148524—

Reaction Steps

4-Hydroxymethyl-indole-1-carboxylic acid tert-butyl ester was synthesized by a procedure similar to 6-hydroxymethyl-indole-1-carboxylic acid tert-butyl ester from starting material 4-formyl-indole-1-carboxylic acid tert-butyl ester to yield the product as a clear viscous oil (0.91 g, 78%). LC-MS (ES) calculated for C14H17NO3, 247.1; found m/z 246 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07947728B1
Source datasetuspto-grants-2011_05
ORD IDord-1c26ff9dcb044f2c8c07742fcab35fd5
Source noteuspto-grants-2011_05