3-[6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid → 3-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid

HRID 551517Notes

Reaction equation

HRID 551517 reaction equation
FC1C(F)=CC(C2C=CC(OCC3C=C4C(C=CN4CCC(O)=O)=CC=3)=CC=2)=C(OC)C=1.C([O:35][C:36](=[O:66])[CH2:37][CH2:38][N:39]1[C:47]2[C:42](=[C:43]([CH2:48][O:49][C:50]3[CH:55]=[CH:54][C:53]([C:56]4[CH:61]=[C:60]([F:62])[C:59]([F:63])=[CH:58][C:57]=4[O:64][CH3:65])=[CH:52][CH:51]=3)[CH:44]=[CH:45][CH:46]=2)[CH:41]=[CH:40]1)C>>[F:63][C:59]1[C:60]([F:62])=[CH:61][C:56]([C:53]2[CH:54]=[CH:55][C:50]([O:49][CH2:48][C:43]3[CH:44]=[CH:45][CH:46]=[C:47]4[C:42]=3[CH:41]=[CH:40][N:39]4[CH2:38][CH2:37][C:36]([OH:66])=[O:35])=[CH:51][CH:52]=2)=[C:57]([O:64][CH3:65])[CH:58]=1

Participants

3

Reactant 2

HCID 529397393-[6-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acidHCID 671519303-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid ethyl ester

Product 1

HCID 529398643-[4-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid

Procedure

3-[4-(4′,5′-Difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid was synthesized by a procedure similar to 3-[6-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid from starting material 3-[4-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-indol-1-yl]-propionic acid ethyl ester to yield the product as a white solid (23 mg, 82%). LC-MS (ES) calculated for C25H21F2NO4, 437.1; found m/z 438 [M+H]+.

Sources & evidence

ORD record
ord-27a658af80c9487b9ec2f4930325b1ed
Source dataset
uspto-grants-2011_05
Patent number
US07947728B1

Reaction notes

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