Hydrazine → HCID 52939866, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-fluoro-5-(4′,5′-difluoro-2′-methoxy-biphenyl-4-yloxymethyl)-benzonitrile (150 mg, 0.41 mmol), aqueous hydrazine (excess) and n-butanol (3 mL) was heated to 150° C. for 30 min via microwave reactor. The mixture was then cooled to room temperature. The mixture was then purified by preparative HPLC under neutral conditions to give title compound. LC-MS (ES) calculated for C21H17F2N3O2, 381.39; found m/z 382 [M+H]+.

Provenance & Evidence