HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(3-Amino-4-methoxyphenethyl)acetamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(4-Methoxy-3-nitrophenethyl)acetamide | HCID 15491289 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(3-Amino-4-methoxyphenethyl)acetamide hydrochloride | HCID 45074592 | 94% |
Reaction Steps
N-[2-(4-methoxy-3-nitrophenyl)ethyl]acetamide (7.4 g) in 150 mL of ethanol was hydrogenated in the presence of 3.5 mL of concentrated HCl and 0.4 g of 10% Pd/C at 30-40 psi for 3 hours in a Parr shaker. After this time, the catalyst was filtered off, and the solvent was removed by rotary evaporation to yield 7.1 g of N-[-2-(3-amino-4-methoxyphenyl)ethyl]acetamide hydrochloride as an off-white solid (94.0% yield). 1HNMR (DMSO-d6) spectrum was consistent with the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07947761B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-bd30d2086dab4740822088470f8b6ef8 |
| Source note | uspto-grants-2011_05 |