Hydrochloric Acid → HCID 75041477, compound

Participants

Reaction Conditions

Reaction Steps

Dimethyl sulfoxide (18.70 mL, 263.3 mmol) was added dropwise over 15 minutes to a dichloromethane (290 mL) solution of oxalic acid chloride (17.30 g, 136.3 mmol) cooled to −78° C., and the mixture was then stirred at −78° C. for 15 minutes. Subsequently, a dichloromethane (75 mL) solution of 2-isopropylpent-4-en-1-ol (11.30 g, 88.1 mmol) was added dropwise thereto over 30 minutes, and the mixture was stirred at −78° C. for 1 hour. Triethylamine (62.40 g, 616.7 mmol) was added dropwise thereto over 5 minutes, and the mixture was then stirred at room temperature for 2 hours. The mixture was neutralized with 2 N hydrochloric acid (320 mL). The organic layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure to obtain a yellow oil substance as a mixture containing the compound of interest. This compound was used in the next reaction without being further purified.

Provenance & Evidence