Triethylamine → HCID 67199341, compound

Participants

Reaction Steps

Tert-butyl(±)-[(1S,5R,6S)-6-(tert-butoxycarbonylaminomethyl)-5-methylbicyclo[3.2.0]hept-3-en-6-yl]acetate (120 mg, 0.34 mmol) was dissolved in a 4 N hydrochloric acid-ethyl acetate solution (2 mL), and the solution was stirred at room temperature for 3 hours and then concentrated under reduced pressure. The residue was dissolved in methylene chloride (2 mL). To the solution, triethylamine (0.048 mL, 0.34 mmol) was added dropwise at room temperature, and the mixture was stirred for 2 hours. The resulting powder was collected by filtration and dried to obtain the compound of interest as a white solid (22 mg).

Provenance & Evidence