p-Toluenesulfonic acid monohydrate → HCID 86646147, compound

Participants

Reaction Steps

Tert-butyl(±)-[(1S,5R,6R)-6-(tert-butoxycarbonylamino)methyl-3,4-dimethylbicyclo[3.2.0]hept-3-en-6-yl]acetate (4.0 g, 11 mmol) and p-toluenesulfonic acid monohydrate (2.5 g, 13 mmol) were suspended in toluene (30 mL) and thioanisole (3.8 mL), and the suspension was stirred at 80° C. for 2 hours. The reaction solution was concentrated, and the resulting oil substance was treated with ethyl acetate and hexane to obtain the title compound (2.3 g, 55%) as a white powder.

Provenance & Evidence