Lithium hydroxide, monohydrate → HCID 86646163, compound

Participants

Reaction Steps

Lithium hydroxide monohydrate (4.39 g, 104 mmol) was added to a tetrahydrofuran:methanol:water (3:3:1, 100 mL) mixed solution of ethyl (2E)-5-ethylhepta-2,6-dienoate (9.52 g, 52.2 mmol), and the mixture was stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure. To the residue, water was then added, followed by washing with diethyl ether. The aqueous layer was made acidic by the addition of 5 M hydrochloric acid, followed by extraction with ethyl acetate. Then, the organic layer was washed with saturated saline and dried over anhydrous sodium sulfate. The residue was filtered and concentrated under reduced pressure to obtain the compound of interest as an oil substance (8.00 g, >99%).

Provenance & Evidence