反应详情

To a solution obtained by adding 1,2-hydrazinedicarboxylic acid bis(2-methoxyethyl) ester (1 g, 4.23 mmol), pyridine (0.34 g, 4.23 mmol), and toluene (10 ml) to a 30 ml flask, followed by cooling with an ice bath, chlorine gas was blown for 30 minutes. After the reaction, the solution was washed with water (1 mL, ×2), and dehumidified with anhydrous magnesium sulfate, followed by concentration to dryness. The solid was recrystallized with toluene (1.5 mL) and hexane (7.5 mL), to give azodicarboxylic acid bis(2-methoxyethyl) ester as a pale yellow crystal (0.59 g, yield: 60%).

1. customTo a solution obtained
2. temperatureby cooling with an ice bath
3. customAfter the reaction
4. washthe solution was washed with water (1 mL, ×2)
5. concentrationfollowed by concentration to dryness
6. customThe solid was recrystallized with toluene (1.5 mL) and hexane (7.5 mL)