HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[4-(7-Chloro-5H-imidazo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl]phenyl]-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-[(2-methylbenzoyl)amino]benzoyl Chloride | HCID 10707441 | — |
| Reactant | 7-chloro-10,11-dihydro-5H-imidazo[2,1-c][1,4]benzodiazepine | HCID 21837100 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(7-Chloro-5H-imidazo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl]phenyl]-2-methylbenzamide | HCID 21837065 | — |
Reaction Steps
As described for Example 125 a mixture of 1 mmol of 7-chloro-10,11-dihydro-5H-imidazo[2,1-c][1,4]-benzodiazepine, 1.1 mmol of 4-[(2-methylbenzoyl)amino]benzoyl chloride and 1.5 mmol of triethylamine in 10 ml of dichloromethane is stirred at room temperature for 3 hours and worked up to give the desired product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624923 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-e5cfd98907d44b03b99802d8ee97f597 |
| Source note | uspto-grants-1997_04 |