Boron tribromide → 5-[4-(3-Hydroxy-pyridin-2-yl)-oxazol-2-yl]-pentanoic acid

HRID 551762Notes

Reaction equation

HRID 551762 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[O:9][CH:10]=[C:11]([C:13]2[C:18]([O:19]C)=[CH:17][CH:16]=[CH:15][N:14]=2)[N:12]=1.B(Br)(Br)Br>>[OH:19][C:18]1[C:13]([C:11]2[N:12]=[C:8]([CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:21])=[O:2])[O:9][CH:10]=2)=[N:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 590278285-[4-(3-Methoxy-pyridin-2-yl)-oxazol-2-yl]-pentanoic acid methyl ester

Product 1

HCID 671699235-[4-(3-Hydroxy-pyridin-2-yl)-oxazol-2-yl]-pentanoic acid

Procedure

Treat 5-[4-(3-methoxy-pyridin-2-yl)-oxazol-2-yl]-pentanoic acid methyl ester with boron tribromide followed by standard hydrolysis to afford the title compound.

Workup

  1. customfollowed by standard hydrolysis

Sources & evidence

ORD record
ord-873d69288ae544ae8be3dff76b76b3b2
Source dataset
uspto-grants-2011_05
Patent number
US07947841B2

Reaction notes

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