Potassium Carbonate → HCID 67187631, compound

Participants

Reaction Steps

A solution of 7 g of 3,4-dihydroquinoline-1(2H)-carbamic acid chloride in 180 ml of acetonitrile is introduced into a 500 ml round-bottomed flask. 9.6 g of bis(2-chloroethyl)amine hydrochloride and 14.83 g of potassium carbonate are subsequently added and the reaction mixture is stirred for 18 h. The acetonitrile is evaporated under reduced pressure and water and ethyl acetate are subsequently added. The aqueous phase is extracted with ethyl acetate and then the organic phases are combined, washed with water and dried over sodium sulfate and then the solvent is evaporated under reduced pressure. The residue is chromatographed on silica gel with a dichloromethane/methanol gradient from 1/0 to 95/5. 2.91 g of N,N-bis(2-chloroethyl)-3,4-dihydroquinoline-1(2H)-carboxamide are obtained.

Provenance & Evidence