反应详情

0.11 g of 1-[(4-(pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline, dissolved in 3 ml of dichloromethane, is introduced into a 25 ml round-bottomed flask. 3.5 ml of a 0.2N solution of hydrochloric acid in ether are subsequently added. Stirring is maintained for 10 min. After evaporating, the residue is taken up in ethyl acetate. The precipitate is filtered off then dried under vacuum. 0.09 g of 1-[(4-(pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride is obtained.

1. additionis introduced into a 25 ml round-bottomed flask
2. temperatureis maintained for 10 min
3. customAfter evaporating
4. filtrationThe precipitate is filtered off
5. customthen dried under vacuum