Hydrochloric Acid → 1-[(4-(Pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride

HRID 551798Notes

Reaction equation

HRID 551798 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[CH2:12][CH2:11][N:10]([C:13]([N:15]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[ClH:25]>ClCCl.CCOCC>[ClH:25].[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[CH2:12][CH2:11][N:10]([C:13]([N:15]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH2:18][CH2:17][CH2:16]3)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 24852909HCID 24852909, compound

Product 1

HCID 248529081-[(4-(Pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

0.11 g of 1-[(4-(pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline, dissolved in 3 ml of dichloromethane, is introduced into a 25 ml round-bottomed flask. 3.5 ml of a 0.2N solution of hydrochloric acid in ether are subsequently added. Stirring is maintained for 10 min. After evaporating, the residue is taken up in ethyl acetate. The precipitate is filtered off then dried under vacuum. 0.09 g of 1-[(4-(pyridin-4-yl)piperidin-1-yl)carbonyl]-1,2,3,4-tetrahydroquinoline hydrochloride is obtained.

Workup

  1. additionis introduced into a 25 ml round-bottomed flask
  2. temperatureis maintained for 10 min
  3. customAfter evaporating
  4. filtrationThe precipitate is filtered off
  5. customthen dried under vacuum

Sources & evidence

ORD record
ord-1e95f9204527467d9f8340ece9eba470
Source dataset
uspto-grants-2011_05
Patent number
US07947834B2

Reaction notes

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